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Blood Logic, Inc. is a nutritional supplement, education, health software and professional consulting company providing services to the general public and to health professionals. Dr. Michael Wald was nicknamed the Blood Detective by a grateful patient when he uncovered the cause of her persistent health problems when many other health care providers had failed. Dr. Wald's motto, branding and exceptional clinical skills have propelled him into the media spotlight appearing on ABC World News Tonight with Diane Sawyer, Fox National News, Channel 11 PIX and many other programs.

Pregnenolone

Pregnenolone

(3-beta-hydroxypregn-5-en-20-one)

A key precursor to cortisol, DHEA and progesterone, pregnenolone promotes normal adrenal function and supports the stress response system by acting as a hormone precursor.

  • 100 Capsules

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$19.95


DESCRIPTION

Pregnenolone (3-beta-hydroxypregn-5-en-20-one)

A key precursor to cortisol, DHEA and progesterone, pregnenolone promotes normal adrenal function and supports the stress response system by acting as a hormone precursor.

Overview

Pregnenolone is a pro-hormone that is synthesized in the brain and adrenals, but also in the liver, skin, brain, testicles, ovaries and retina. As a biochemical precursor to DHEA and progesterone, pregnenolone helps to keep a normal balance between these hormones in the body and as a result, helps to modulate the cortisol-driven stress response system, support nerve cell growth and modulate mood. Specifically, when a high-stress lifestyle pushes the stress response system into overdrive, the rise in cortisol can ultimately cause the depletion of pregnenolone and a reduced availability of DHEA and progesterone. This phenomenon is known as "pregnenolone steal," and supplementing pregnenolone can help to replace this needed precursor.
Pregnenolone plays a key role in hormonal balance as a key precursor to cortisol, DHEA and progesterone, and helps to maintain balance in the body’s stress response system. In addition, pregnenolone has been shown to support a balanced mood and promote cognitive health by modulating the transmission of messages between neurons, influencing learning and memory processes. Since there is strong evidence that pregnenolone levels diminish with advancing age, restoring these levels may also help support overall brain function and sense of well-being. Each capsule of the Pregneolone formula includes 10 mg of pregnenolone in a scored, quick-dissolve tablet, allowing for incremental dosing as needed.

Suggested Use

One or more tablets per day or as recommended by your health care professional.

Clinical Applications

    •    Promotes Normal Hormonal Balance
    •    Helps Maintain Healthy Memory and Cognitive Function
    •    Supports Mood Regulation
    •    Supports the Stress Response System by Acting As Hormonal Precursor

Ingredients Benefits

Pregnenolone
Pregnenolone plays a key role in hormonal balance as a key precursor to cortisol, DHEA and progesterone, and helps to maintain balance in the body’s stress response system. In addition to its function as a prohormone, pregnenolone is a neurosteroid that is found in high concentrations in the brain where it protects neurons, enhances myelination and supports cognitive health and memory. Pregnenolone supplementation is particularly important for those who have been found to have deficient hormone levels through testing, as well as those who need cortisol to DHEA ratio support.

References

1. Stomati M, Monteleone P, Casarosa E, et al. Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause. Gynecol Endocrinol. 2000 Oct;14(5):342-63.

2. Vallee M, Purdy RH, Mayo W, Koob GF, Le MM. Neuroactive steroids: new biomarkers of cognitive aging. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):329-35.

3. Ritsner, M. S. Pregnenolone, dehydroepiandrosterone, and schizophrenia: alterations and clinical trials. CNS Neurosci Ther. 2010; 16(1):32-44).

4. Ritsner M, Maayan R, Gibel A, Weizman A. Differences in blood pregnenolone and dehydroepiandrosterone levels between schizophrenia patients and healthy subjects. Eur Neuropsychopharmacol. 2007 Apr;17(5):358- 65.

5. Ritsner MS, Gibel A, Shleifer T, Boguslavsky I, Zayed A, Maayan R, Weizman A, Lerner V. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallelgroup trial. J Clin Psychiatry. 2010 Oct;71(10):1351-62.

6. Vallée M, Mayo W, Le Moal M. Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Res Brain Res Rev. 2001 Nov;37(1-3):301-12.

7. Meziane H, Mathis C, Paul SM, Ungerer A. The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice performing an appetitive learning task. Psychopharmacology (Berl). 1996 Aug;126(4):323-30.

8. Mayo W, Le Moal M, Abrous DN. Pregnenolone sulfate and aging of cognitive functions: behavioral, neurochemical, and morphological investigations. Horm Behav. 2001 Sep;40(2):215-7.

9. Marx CE, Bradford DW, Hamer RM, Naylor JC, Allen TB, Lieberman JA, Strauss JL, Kilts JD. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience. 2011 Sep 15;191:78-90. 10. Wu FS, Gibbs TT, Farb DH. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol. 1991 Sep;40(3):333-6.

These statements have not been evaluated by the Food & Drug Administration (FDA) and are for educational purposes only and are not meant as medical or health advice. Please consult with your doctor before taking nutritional supplements.